HCID 25248372, compound → HCID 19627217, compound

HRID 1592817Notes

Reaction equation

HRID 1592817 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CCO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 25248372HCID 25248372, compound

Product 1

HCID 19627217HCID 19627217, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-Fluoro-4-nitro-1-phenoxybenzene and 7.2 g of 10% Pd/C were dissolved in 200 mL EtOH and stirred under 1 atmosphere of H2 overnight. The reaction mixture was filtered through Celite with the aid of 50 mL EtOH and concentrated to provide 3-fluoro-4-phenoxybenzenamine as an oil which was used in Step C without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through Celite with the aid of 50 mL EtOH
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-59ba03bb420749c99fbb16526e42678d
Source dataset
uspto-grants-2007_11
Patent number
US07294616B2

Reaction notes

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