HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-{[(Methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-t-Butoxycarbonyl-4-{[(methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine | HCID 69427854 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-{[(Methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine hydrochloride | HCID 69428721 | 100% |
Reaction Steps
Hydrogen chloride gas is passed through a methanol (500 mL) solution of 1-t-butoxycarbonyl-4-{[(methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine maintaining <20° C., for 5 minutes. The mixture is kept at this temperature for 1 hour before it is concentrated in vacuo providing 4-{[(methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine hydrochloride (430 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07294627B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-04771340f47f4819803e8d47d850f144 |
| Source note | uspto-grants-2007_11 |