Hydrochloric Acid → 4-{[(Methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine hydrochloride

HRID 1592858Notes

Reaction equation

HRID 1592858 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][N:16]([CH3:27])[C:17]2[CH:22]=[CH:21][N:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[CH3:27][N:16]([CH2:15][CH:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)[C:17]1[CH:22]=[CH:21][N:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 694278541-t-Butoxycarbonyl-4-{[(methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine

Product 1

HCID 694287214-{[(Methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrogen chloride gas is passed through a methanol (500 mL) solution of 1-t-butoxycarbonyl-4-{[(methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine maintaining <20° C., for 5 minutes. The mixture is kept at this temperature for 1 hour before it is concentrated in vacuo providing 4-{[(methyl)(2-trifluoromethylpyridin-4-yl)amino]methyl}piperidine hydrochloride (430 mg, 100%).

Workup

  1. concentrationis concentrated in vacuo

Sources & evidence

ORD record
ord-04771340f47f4819803e8d47d850f144
Source dataset
uspto-grants-2007_11
Patent number
US07294627B2

Reaction notes

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