Hydrochloric Acid → HCID 69432235, compound

Participants

Reaction Steps

Hydrogen chloride gas is passed through a methanol (500 mL) solution of 1-t-butoxycarbonyl-4-{[(methyl)(pyridin-4-yl)amino]methyl}piperidine maintaining <20° C., for 5 minutes. The mixture is kept at this temperature for 7 hours, then at 4° C. for 16 hours before it is concentrated in vacuo providing 4-{[(methyl)(pyridin-4-yl)amino]methyl}piperidine hydrochloride (4.85 g, >100%).

Provenance & Evidence