Hydrochloric Acid → HCID 69432235, compound

HRID 1592862Notes

Reaction equation

HRID 1592862 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][N:16]([CH3:23])[C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[CH3:23][N:16]([CH2:15][CH:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)[C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69426437HCID 69426437, compound

Product 1

HCID 69432235HCID 69432235, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrogen chloride gas is passed through a methanol (500 mL) solution of 1-t-butoxycarbonyl-4-{[(methyl)(pyridin-4-yl)amino]methyl}piperidine maintaining <20° C., for 5 minutes. The mixture is kept at this temperature for 7 hours, then at 4° C. for 16 hours before it is concentrated in vacuo providing 4-{[(methyl)(pyridin-4-yl)amino]methyl}piperidine hydrochloride (4.85 g, >100%).

Workup

  1. concentrationat 4° C. for 16 hours before it is concentrated in vacuo

Sources & evidence

ORD record
ord-efe14952ecd74dd8b1f62c7f5d783114
Source dataset
uspto-grants-2007_11
Patent number
US07294627B2

Reaction notes

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