HCID 23080626, compound → HCID 9975884, compound

HRID 1592884Notes

Reaction equation

C(OC([CH2:8][NH:9][C:10]1[CH:15]=[C:14]([C:16]2[C:17]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)=[N:18][N:19]([C:21]3[N:22]=[N:23][C:24](Cl)=[CH:25][CH:26]=3)[CH:20]=2)[CH:13]=[CH:12][N:11]=1)=O)(C)(C)C.C([O:39]C(NC1C=C(C2C(C3C=CC(F)=CC=3)=NN(C3N=NC(Cl)=CC=3)C=2)C=CN=1)=O)(C)(C)C>>[F:34][C:31]1[CH:32]=[CH:33][C:28]([C:17]2[C:16]([C:14]3[CH:13]=[CH:12][N:11]=[C:10]([NH:9][CH3:8])[CH:15]=3)=[CH:20][N:19]([C:21]3[CH:26]=[CH:25][C:24](=[O:39])[NH:23][N:22]=3)[N:18]=2)=[CH:29][CH:30]=1

Participants

Reactant 2

HCID 23080626HCID 23080626, compound

HCID 86604013HCID 86604013, compound

Product 1

HCID 9975884HCID 9975884, compoundYield 89%

Procedure

The reaction was carried out in the same manner as in Example 2-4) except for using 330 mg (0.69 mmol) of 4-{2-[(t-butoxycarbonyl)methylamino]pyridin-4-yl}-1-(6-chloropyridazin-3-yl)-3-(4-fluorophenyl)-1H-pyrazole obtained in Example 3-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-1-(6-chloropyridazin-3-yl)-3-(4-fluorophenyl)-1H-pyrazole to obtain 222 mg of the title compound as a pale beige powder. (Yield: 89%)

Sources & evidence

ORD record: ord-7c87e218da8b47e8acdd2d2abd6341ae
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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