3-(Dimethylamino)-1-(4-fluorophenyl)-2-(pyridin-4-yl)prop-2-en-1-one → HCID 178505589, compound

HRID 1592885Notes

Reaction equation

HRID 1592885 reaction equation
C[N:2](C)[CH:3]=[C:4]([C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1)[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([F:14])[CH:8]=1)=O.C[N:23](C)C=C(C1C=CN=CC=1)C(C1C=CC(F)=CC=1)=O>>[F:14][C:9]1[CH:8]=[C:7]([C:5]2[C:4]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)=[CH:3][NH:2][N:23]=2)[CH:12]=[CH:11][C:10]=1[F:13]

Participants

3

Reactant 2

HCID 545188383-(Dimethylamino)-1-(4-fluorophenyl)-2-(pyridin-4-yl)prop-2-en-1-oneHCID 694130903-Dimethylamino-1-(3,4-difluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one

Product 1

HCID 178505589HCID 178505589, compoundYield 90%

Procedure

The reaction was carried out in the same manner as in Example 1-2) except for using 2.54 g (8.81 mmol) of 3-dimethylamino-1-(3,4-difluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one obtained in Example 6-1) in place of 3-dimethylamino-1-(4-fluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one to obtain 2.05 g of the title compound as a white powder. (Yield: 90%)

Sources & evidence

ORD record
ord-5abb74c0ce5a4d6a80d773e6859727d4
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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