HCID 69414044, compound → HCID 9978315, compound

HRID 1592887Notes

Reaction equation

C(OC([CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[C:15]([C:17]2[C:18]([C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)=[N:19][N:20]([C:22]3[CH:23]=[CH:24][C:25]4[N:26]([CH:28]=[N:29][N:30]=4)[N:27]=3)[CH:21]=2)[CH:14]=[CH:13][N:12]=1)=O)(C)(C)C.C(OC(NC1C=C(C2C(C3C=CC(F)=CC=3)=NN(C3C=CC4N(C=NN=4)N=3)C=2)C=CN=1)=O)(C)(C)C>>[CH2:9]([NH:10][C:11]1[CH:16]=[C:15]([C:17]2[C:18]([C:31]3[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=3)=[N:19][N:20]([C:22]3[CH:23]=[CH:24][C:25]4[N:26]([CH:28]=[N:29][N:30]=4)[N:27]=3)[CH:21]=2)[CH:14]=[CH:13][N:12]=1)[CH3:8]

Participants

Reactant 2

HCID 69414044HCID 69414044, compound

HCID 69415264HCID 69415264, compound

Product 1

HCID 9978315HCID 9978315, compoundYield 78.1%

Procedure

The reaction was carried out in the same manner as in Example 8-2) except for using 659 mg (1.32 mmol) of 4-{2-[(t-butoxycarbonyl)ethylamino]pyridin-4-yl}-3-(4-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained in Example 14-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-(4-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole to obtain 413 mg of the title compound as a beige powder. (Yield: 78%)

Sources & evidence

ORD record: ord-76113f0bda794956a3dff681ecd03332
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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