2-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-phenyl-2-propen-1-one → HCID 178452638, compound

HRID 1592889Notes

Reaction equation

HRID 1592889 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15](=[CH:24][N:25](C)C)[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=O)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC([NH:35]C1C=C(C(=CN(C)C)C(C2C=CC(F)=CC=2)=O)C=CN=1)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:35][NH:25][CH:24]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 694141522-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-phenyl-2-propen-1-oneHCID 694159932-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one

Product 1

HCID 178452638HCID 178452638, compoundYield 86%

Procedure

The reaction was carried out in the same manner as in Example 2-2) except for using 18.4 g (50.0 mmol) of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-phenyl-2-propen-1-one obtained in Example 20-1) in place of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one to obtain 14.5 g of the title compound as a white powder. (Yield: 86%)

Sources & evidence

ORD record
ord-5e48ee8918f544b2b3a5ccecf7cc0d24
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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