2-(2-t-Butoxycarbonylaminopyridin-4-yl)-1-(4-chlorophenyl)-3-dimethylamino-2-propen-1-one → HCID 178452641, compound

HRID 1592892Notes

Reaction equation

HRID 1592892 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15](=[CH:25][N:26](C)C)[C:16]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)=O)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC([NH:36]C1C=C(C(=CN(C)C)C(C2C=CC(F)=CC=2)=O)C=CN=1)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)=[N:36][NH:26][CH:25]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 694134312-(2-t-Butoxycarbonylaminopyridin-4-yl)-1-(4-chlorophenyl)-3-dimethylamino-2-propen-1-oneHCID 694159932-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one

Product 1

HCID 178452641HCID 178452641, compoundYield 97%

Procedure

The reaction was carried out in the same manner as in Example 2-2) except for using 10.1 g (25.0 mmol) of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-1-(4-chlorophenyl)-3-dimethylamino-2-propen-1-one obtained in Example 23-1) in place of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one to obtain 9.01 g of the title compound as a pale yellowish white powder. (Yield: 97%)

Sources & evidence

ORD record
ord-49bd705f3e644a0b9df1294f129a03b6
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

Loading…