Tetrahydrofuran → HCID 10451400, compound

Participants

Reaction Steps

The reaction was carried out in the same manner as in Example 33 except for using 100 mg (0.29 mmol) of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3-yl)-1H-pyrazole obtained in Example 50 in place of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-1H-pyrazole, and using 3 ml of N,N-dimethylformamide as a solvent in place of tetrahydrofuran to obtain 39.5 mg of the title compound as a white powder. (Yield: 38%)

Provenance & Evidence