Tetrahydrofuran → HCID 10451400, compound

HRID 1592915Notes

Reaction equation

HRID 1592915 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[N:10][N:11]([C:13]3[CH2:18][CH2:17][C:16](=[O:19])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.O1CCC[CH2:28]1>CN(C)C=O>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)=[N:10][N:11]([C:13]3[CH2:18][CH2:17][C:16](=[O:19])[N:15]([CH3:28])[N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 10427935HCID 10427935, compound

Product 1

HCID 10451400HCID 10451400, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The reaction was carried out in the same manner as in Example 33 except for using 100 mg (0.29 mmol) of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3-yl)-1H-pyrazole obtained in Example 50 in place of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-1H-pyrazole, and using 3 ml of N,N-dimethylformamide as a solvent in place of tetrahydrofuran to obtain 39.5 mg of the title compound as a white powder. (Yield: 38%)

Sources & evidence

ORD record
ord-8619ef8cab224c59aa29b9370ae04a0a
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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