3-Dimethylamino-1-(4-fluorophenyl)-2-(2-methylthiopyrimidin-4-yl)-2-propen-1-one → HCID 178503425, compound

HRID 1592920Notes

Reaction equation

HRID 1592920 reaction equation
C[N:2](C)[CH:3]=[C:4]([C:14]1[CH:19]=[CH:18][N:17]=[C:16]([S:20][CH3:21])[N:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=O.C(OC([NH:30]C1C=C(C(=CN(C)C)C(C2C=CC(F)=CC=2)=O)C=CN=1)=O)(C)(C)C>>[F:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[C:4]([C:14]3[CH:19]=[CH:18][N:17]=[C:16]([S:20][CH3:21])[N:15]=3)=[CH:3][NH:2][N:30]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 670737613-Dimethylamino-1-(4-fluorophenyl)-2-(2-methylthiopyrimidin-4-yl)-2-propen-1-oneHCID 694159932-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one

Product 1

HCID 178503425HCID 178503425, compoundYield 93%

Procedure

The reaction was carried out in the same manner as in Example 2-2) except for using 4.13 g (13.0 mmol) of 3-dimethylamino-1-(4-fluorophenyl)-2-(2-methylthiopyrimidin-4-yl)-2-propen-1-one obtained in Example 66-1) in place of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one to obtain 3.44 g of the title compound as a white powder. (Yield: 93%)

Sources & evidence

ORD record
ord-0e9eaa3b719e4a30ababfa537803958f
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

Loading…