Potassium Carbonate → HCID 17864576, compound

HRID 1592946Notes

Reaction equation

HRID 1592946 reaction equation
[CH3:1][C:2]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)([CH3:5])[C:3]#[CH:4].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]#[N:21]>C(C(C)=O)C>[CH3:5][C:2]([N:6]1[CH2:7][CH2:8][N:9]([CH2:19][C:20]#[N:21])[CH2:10][CH2:11]1)([CH3:1])[C:3]#[CH:4]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 178645771-(2-Methylbut-3-yn-2-yl)piperazine

Product 1

HCID 17864576HCID 17864576, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent2×

Procedure

To a suspension (10 mL) of 1-(1,1-dimethyl-2-propynyl)piperazine (350 mg, 2.3 mmol) and potassium carbonate (480 mg, 3.45 mmol) in methyl ethyl ketone (MEK) was added bromoacetonitrile (0.176 mL, 2.53 mmol), and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with MEK and filtered. The filtrate was concentrated to give the title compound (0.439 g, quantitative) as a white solid.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-15682edb23f54c938c3e2e618456592d
Source dataset
uspto-grants-2007_11
Patent number
US07294629B2

Reaction notes

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