HCID 69238888, compound → HCID 11681372, compound

HRID 1593017Notes

Reaction equation

HRID 1593017 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[CH:12][C:13](N2[C@H](C3C=CC=CC=3)[C@H](C)N(C)C2=O)=[O:14])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[F:29][C:30]1[CH:31]=[C:32]([Mg]Br)[CH:33]=[C:34]([F:36])[CH:35]=1.C1([C@@H](C2C=CC(S(C)(=O)=O)=CC=2)CC=O)C=CC=CC=1>>[F:29][C:30]1[CH:31]=[C:32]([C@@H:11]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:10][CH:9]=2)[CH2:12][CH:13]=[O:14])[CH:33]=[C:34]([F:36])[CH:35]=1

Participants

4

Reactant 3

HCID 69238888HCID 69238888, compoundHCID 86603571HCID 86603571, compound2×HCID 178505930HCID 178505930, compound

Product 1

HCID 11681372HCID 11681372, compound

Procedure

This was prepared from (4S,5R)-1-(3-[4-methanesulfonylphenyl]acryloyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one and 3,5-difluorophenylmagnesium bromide using a method similar to that used to prepare (S)-3-phenyl-3-(4-methanesulfonyl-phenyl)propionaldehyde from phenylmagnesium bromide (Method N).

Sources & evidence

ORD record
ord-82575cb1e13b4614ae56b75108172578
Source dataset
uspto-grants-2007_11
Patent number
US07294636B2

Reaction notes

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