Hydrochloric Acid → HCID 45094991, compound

HRID 1593022Notes

Reaction equation

HRID 1593022 reaction equation
[CH2:1]([CH:3]1[C:7](=[O:8])[N:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[C:5](=[O:22])[NH:4]1)[CH3:2].Cl.C(OCC)C>O1CCOCC1>[CH2:1]([CH:3]1[NH:4][C:5](=[O:22])[N:6]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:7]1=[O:8])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69448964HCID 69448964, compound

Product 1

HCID 45094991HCID 45094991, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a suspension of tert-butyl 4-(4-ethyl-2,5-dioxoimidazolidin-1-yl)piperidine-1-carboxylate (1.12 g) in dioxane (10 ml) was added a solution of 4M HCl in dioxane (10 ml) and the resulting mixture was stirred for 1 hour. Diethyl ether (20 ml) was added and the mixture was filtered and washed with diethyl ether to give 5-ethyl-3-piperidin-4-ylimidazolidine-2,4-dione. Yield 687 mg. MS 212 MH+

Workup

  1. filtrationthe mixture was filtered
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-eb36e12cfd174a43ad4c119609322543
Source dataset
uspto-grants-2007_11
Patent number
US07294636B2

Reaction notes

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