反应详情

To a solution of 8-benzylbicyclo[3.2.1.]octan-3-one (13.66 g) in ethanol (250 ml) was added pyridine (5.69 ml) followed by hydroxylamine hydrochloride (4.85 g) and the resulting mixture was refluxed for 18 hours. The reaction mixture was allowed to cool to room temperature and then partitioned between water and dichloromethane. The organic layer was dried and evaporated to give the title compound as a brown solid which was used without further purification. Yield 10.79 g. MS 231 MH+.

1. temperaturethe resulting mixture was refluxed for 18 hours
2. custompartitioned between water and dichloromethane
3. customThe organic layer was dried
4. customevaporated