Trifluoroacetic acid → HCID 58998473, compound

HRID 1593062Notes

Reaction equation

C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([NH:12][C:13]([NH:15][S:16]([C:19]2[S:20][C:21]([Cl:24])=[CH:22][CH:23]=2)(=[O:18])=[O:17])=[O:14])[CH:9]=[CH:8][C:7]=1[N:25]1[CH:34]=[CH:33][C:32]2[C:27](=[CH:28][C:29]([F:37])=[C:30]([NH:35][CH3:36])[CH:31]=2)[C:26]1=[O:38])(=O)C.C(O)(C(F)(F)F)=O>>[Cl:24][C:21]1[S:20][C:19]([S:16]([NH:15][C:13]([NH:12][C:10]2[CH:9]=[CH:8][C:7]([N:25]3[CH:34]=[CH:33][C:32]4[C:27](=[CH:28][C:29]([F:37])=[C:30]([NH:35][CH3:36])[CH:31]=4)[C:26]3=[O:38])=[C:6]([CH2:5][OH:4])[CH:11]=2)=[O:14])(=[O:17])=[O:18])=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 58998496HCID 58998496, compound

Product 1

HCID 58998473HCID 58998473, compound

Procedure

This analog compound was obtained from hydrolysis of the intermediate, Boc protected compound of Example 62, then followed by TFA deprotection to give 5-chloro-N-({[4-[7-fluoro-6-(methylamino)-1-oxoisoquinolin-2(1H)-yl]-3-(hydroxymethyl)phenyl]amino}carbonyl)thiophene-2-sulfonamide. ES-MS (M+H)+=537, 539(Cl).

Sources & evidence

ORD record: ord-cd54bb1e349d40f3b5c1491c83db6339
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294635B2

Reaction notes

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