反应详情

To a solution of 2-fluoro-5-nitro-benzoic acid (0.269 g, 1.45 mmol) in 3 mL ethanol, was added concentrated sulfuric acid (0.5 ml). The solution was refluxed under argon for 3 hours. The mixture was stirred at room temperature for 2 hours, then diluted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate, concentrated in vacuo to give pure 2-fluoro-5-nitro-benzoic acid ethyl ester.

1. temperatureThe solution was refluxed under argon for 3 hours
2. washwashed with brine
3. dry with materialThe organic layer was dried over sodium sulfate
4. concentrationconcentrated in vacuo