2-Ethynyl-1-fluoro-4-nitrobenzene → HCID 19702702, compound

HRID 1593068Notes

Reaction equation

HRID 1593068 reaction equation
[C:1]([C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[F:12])#[CH:2]>C(O)C.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[F:12][C:4]1[CH:5]=[CH:6][C:7]([N+:9]([O-:11])=[O:10])=[CH:8][C:3]=1[CH:1]=[CH2:2]

Participants

4

Reactant 1

HCID 126873612-Ethynyl-1-fluoro-4-nitrobenzene

Product 1

HCID 19702702HCID 19702702, compound

Reagents, catalysts & solvents 2

HCID 16218511Pd barium sulfateCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-ethynyl-1-fluoro-4-nitro-benzene (70 mg, 0.42 mmol, obtained in Example 71) in 3 mL ethanol, 5% Pd/BaSO4 (48 mg) was added. The mixture was hydrogenated at 1 atm for 1.5 hrs. Catalyst was removed by filtering through a celite pad. The filtrate was concentrated to give pure 1-fluoro-4-nitro-2-vinyl-benzene.

Workup

  1. customCatalyst was removed
  2. filtrationby filtering through a celite pad
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-728e180744624e8f8c559f41448dc995
Source dataset
uspto-grants-2007_11
Patent number
US07294635B2

Reaction notes

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