Sodium methanesulfinate → HCID 58998479, compound

HRID 1593078Notes

Reaction equation

HRID 1593078 reaction equation
[C:1]([O:5][C:6](=[O:31])[N:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[C:15](=[O:20])[N:14]([C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[C:23](Br)[CH:22]=1)[CH:13]=[CH:12]2)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[CH3:32][S:33]([O-:35])=[O:34].[Na+]>CS(C)=O>[C:1]([O:5][C:6](=[O:31])[N:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[C:15](=[O:20])[N:14]([C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[C:23]([S:33]([CH3:32])(=[O:35])=[O:34])[CH:22]=1)[CH:13]=[CH:12]2)[CH3:8])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 2733271Sodium methanesulfinateHCID 58998403HCID 58998403, compound

Product 1

HCID 58998479HCID 58998479, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a slolution of [2-(3-bromo-4-nitro-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester (10 mg, 0.02 mmol) in DMSO 0.5 ml, sodium methanesulfinate (62 mg, 0.06 mmol) was added. The reaction mixture was subjected to microwave irradiation (temperature 12° C.) for 45 seconds. A precipitate was formed and collected by filtration to give [7-fluoro-2-(3-methanesulfonyl-4-nitro-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester.

Workup

  1. customThe reaction mixture was subjected to microwave irradiation (temperature 12° C.) for 45 seconds
  2. customA precipitate was formed
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-05eb4f0bb555425bbd3a99bb7563c29f
Source dataset
uspto-grants-2007_11
Patent number
US07294635B2

Reaction notes

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