3-Amino-1-propanol → HCID 58999112, compound

HRID 1593138Notes

Reaction equation

HRID 1593138 reaction equation
[CH:1]1([CH2:7][N:8]2[C:12]([C:13]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=3[O:21][CH3:22])=[CH:11][C:10]([C:23](O)=[O:24])=[C:9]2[CH3:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:27][CH2:28][CH2:29][CH2:30][OH:31]>>[OH:31][CH2:30][CH2:29][CH2:28][NH:27][C:23]([C:10]1[CH:11]=[C:12]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[O:21][CH3:22])[N:8]([CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:9]=1[CH3:26])=[O:24]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 68839395HCID 68839395, compound

Product 1

HCID 58999112HCID 58999112, compound

Procedure

The coupling reaction between 1-cyclohexylmethyl-5-(2,5-dimethoxy-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid and 3-amino-propan-1-ol was similar to the reaction exemplified in the synthesis of Example 49 to give 1-cyclohexylmethyl-5-(2,5-dimethoxy-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid (3-hydroxy-propyl)-amide; MS (ISP) 415.3 (M+H)+.

Workup

  1. customexemplified in the synthesis of Example 49

Sources & evidence

ORD record
ord-465cb941594343268d72d149556fa031
Source dataset
uspto-grants-2007_11
Patent number
US07294644B2

Reaction notes

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