Methyl acetoacetate → HCID 58999174, compound

HRID 1593172Notes

Reaction equation

HRID 1593172 reaction equation
CO[C:3](=[O:8])[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([F:19])[C:16]([Cl:20])=[CH:15][C:14]=1[Cl:21])=O.[NH2:22][CH2:23][C:24]1([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[OH:30][C:24]1([CH2:23][NH:22][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[C:17]([F:19])[C:16]([Cl:20])=[CH:15][C:14]=3[Cl:21])[N:22]([CH2:23][CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[C:5]=2[CH3:6])=[O:8])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 7757Methyl acetoacetateHCID 776141-(Aminomethyl)cyclohexan-1-olHCID 11150335HCID 11150335, compound

Product 1

HCID 58999174HCID 58999174, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2,4-dichloro-5-fluorophenyl)-ethanone as compound of formula S, c-cyclohexyl-methylamine as R3—(CH2)m—NH2 and 1-aminomethyl-1-cyclohexanol as R1R2NH, MS (ISP) 495.5 (M+H)+.

Sources & evidence

ORD record
ord-18e0970acae04505a74522daa99e030c
Source dataset
uspto-grants-2007_11
Patent number
US07294644B2

Reaction notes

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