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Methyl acetoacetate → 5-(2,5-Bis-trifluoromethyl-phenyl)-1-(2-cyclopropyl-ethyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| 反応物 | Cyclopropaneethanamine | HCID 10240761 | — |
| 反応物 | 1-(2,5-Bis-trifluoromethyl-phenyl)-2-bromo-ethanone | HCID 22137987 | — |
| 生成物 | 5-(2,5-Bis-trifluoromethyl-phenyl)-1-(2-cyclopropyl-ethyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide | HCID 10255487 | — |
反応手順
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(2,5-bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, 2-cyclopropyl-ethylamine as R3—(CH2)m—NH2 and (1R,2R)-2-amino-cyclohexanol as R1R2NH, MS (ISP) 503.1 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07294644B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-0c9de351af6c4a25880b58827649b252 |
| 出典メモ | uspto-grants-2007_11 |