2-methyl-5-(trifluoromethyl)benzoyl Chloride → 1-[2-Methyl-5-(trifluoromethyl)phenyl]ethan-1-one

HRID 1593194Notes

Reaction equation

HRID 1593194 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:15][Mg]Br>C1COCC1>[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4](=[O:5])[CH3:15]

Participants

4

Reactant 2

HCID 27756042-methyl-5-(trifluoromethyl)benzoyl ChlorideHCID 178418573HCID 178418573, compound

Product 1

HCID 467375221-[2-Methyl-5-(trifluoromethyl)phenyl]ethan-1-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was synthesized from 2-methyl-5-(trifluoromethyl)-benzoyl chloride via the reaction of the corresponding Weinreb amide with methyl magnesium bromide in THF.

Sources & evidence

ORD record
ord-b616e91fe8c34f30a5c3737d68d2b3b7
Source dataset
uspto-grants-2007_11
Patent number
US07294644B2

Reaction notes

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