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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1593197Generated: October 27, 2026

Methyl acetoacetate → HCID 58999090, compound

https://huagongshe.com/reaction/1593197

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl acetoacetateHCID 7757—
Reactant(1R,2R)-2-AminocyclohexanolHCID 735777—
Reactant2-Chloro-5-(trifluoromethyl)phenacyl bromideHCID 2783183—
Reactantcis-2-Aminomethyl-1-cyclohexanolHCID 12483365—
ProductHCID 58999090HCID 58999090—

Reaction Steps

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-chloro-5-trifluoromethyl-phenyl)-ethanone as compound of formula S, cis-2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and (1R,2R)-2-amino-cyclohexanol as R1R2NH, MS (ISP) 513.5 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07294644B2
Source datasetuspto-grants-2007_11
ORD IDord-ab372048040b47439be50b80cb1cb9b0
Source noteuspto-grants-2007_11