Methyl acetoacetate → HCID 58999090, 화합물

HRID 1593197노트

반응식

HRID 1593197 반응식
CO[C:3](=[O:8])[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=1[Cl:23])=O.[NH2:24][CH2:25][C@H:26]1[CH2:31][CH2:30][CH2:29][CH2:28][C@H:27]1[OH:32].[NH2:33][C@@H:34]1[CH2:39][CH2:38][CH2:37][CH2:36][C@H:35]1[OH:40]>>[OH:40][C@@H:35]1[CH2:36][CH2:37][CH2:38][CH2:39][C@H:34]1[NH:33][C:3]([C:4]1[CH:10]=[C:11]([C:13]2[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=2[Cl:23])[N:24]([CH2:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]2[OH:32])[C:5]=1[CH3:6])=[O:8]

참가 물질

5

반응물 4

HCID 7757Methyl acetoacetateHCID 735777(1R,2R)-2-AminocyclohexanolHCID 27831832-Chloro-5-(trifluoromethyl)phenacyl bromideHCID 12483365cis-2-Aminomethyl-1-cyclohexanol

생성물 1

HCID 58999090HCID 58999090, 화합물

실험 절차

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-chloro-5-trifluoromethyl-phenyl)-ethanone as compound of formula S, cis-2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and (1R,2R)-2-amino-cyclohexanol as R1R2NH, MS (ISP) 513.5 (M+H)+

출처 및 근거

ORD 기록
ord-ab372048040b47439be50b80cb1cb9b0
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294644B2

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