反应详情

2-Carbamoylmethoxy-4-{(5-methoxy-2-nitrophenyl)aminosulfonyl}phenoxyacetamide (Intermediate A67, 14 g, 0.031 mol) in 100 mL of dimethylacetamide was hydrogenated with platinum oxide (0.50 g, 0.0022 mol) as catalyst. After the catalyst was filtered off, the mixture was concentrated under high vacuum. The residue was triturated successively with 1:1 hexanes:ethyl acetate and 2:1 dichloromethane:hexanes. The collected solid, title compound, weighed 12.8 g (97%) after air-drying.

1. filtrationAfter the catalyst was filtered off
2. concentrationthe mixture was concentrated under high vacuum
3. customThe residue was triturated successively with 1:1 hexanes
4. customafter air-drying