Dimethylformamide → 5-[1-(3,4-Difluorobenzyl)piperidin-4-ylmethoxy]quinazoline-2,4-diamine
Reaction equation
[CH3:31][N:32]([CH3:33])[CH:34]=[O:35].[F:21][c:22]1[cH:23][c:24]([CH2:25][Br:26])[cH:27][cH:28][c:29]1[F:30].[NH:1]1[CH2:2][CH2:3][CH:4]([CH2:7][O:8][c:9]2[c:10]3[c:11]([NH2:20])[n:12][c:13]([NH2:19])[n:14][c:15]3[cH:16][cH:17][cH:18]2)[CH2:5][CH2:6]1>>[N:1]1([CH2:25][c:24]2[cH:23][c:22]([F:21])[c:29]([F:30])[cH:28][cH:27]2)[CH2:2][CH2:3][CH:4]([CH2:7][O:8][c:9]2[c:10]3[c:11]([NH2:20])[n:12][c:13]([NH2:19])[n:14][c:15]3[cH:16][cH:17][cH:18]2)[CH2:5][CH2:6]1Participants
4
Sources & evidence
- ORD record
- ord-cf27b670dc194c94a6f323ac96969795
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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