反应详情

Into 150 ml of dichloromethane was dissolved 15.0 g of tert-butyl (2R,5S)-4-(4-cyano-3-fluorophenyl)-2,5-dimethylpiperazine-1-carboxylate, and then 30 ml of trifluoroacetic acid was added thereto, followed by stirring at room temperature overnight. After the reaction solution was removed by evaporation, 1M hydrochloric acid was added thereto, followed by washing with chloroform. The aqueous phase was made basic with a 5M sodium hydroxide aqueous solution, followed by extraction with chloroform. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was removed by evaporation to obtain 12.0 g of the title compound.

1. customAfter the reaction solution was removed by evaporation, 1M hydrochloric acid
2. additionwas added
3. washby washing with chloroform
4. extractionfollowed by extraction with chloroform
5. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
6. customthe solvent was removed by evaporation