4-Pyridinecarboxaldehyde → 4-[4(2-Dimethylaminoethoxy)phenyl]-2-(1-methoxyiminoindan-5-yl)-1-pyridin-4-ylbutane-1,4-dione

HRID 1593419Notes

Reaction equation

HRID 1593419 reaction equation
[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[CH:8][C:9](/[CH:13]=[CH:14]/[C:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][N:26]([CH3:28])[CH3:27])=[CH:19][CH:18]=3)=[O:16])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.[N:29]1[CH:34]=[CH:33][C:32]([CH:35]=[O:36])=[CH:31][CH:30]=1>>[CH3:27][N:26]([CH3:28])[CH2:25][CH2:24][O:23][C:20]1[CH:19]=[CH:18][C:17]([C:15](=[O:16])[CH2:14][CH:13]([C:9]2[CH:8]=[C:7]3[C:12](=[CH:11][CH:10]=2)[C:4](=[N:3][O:2][CH3:1])[CH2:5][CH2:6]3)[C:35]([C:32]2[CH:33]=[CH:34][N:29]=[CH:30][CH:31]=2)=[O:36])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 865954105-{(E)-3-[4-(2-Dimethylamino-ethoxy)-phenyl]-3-oxo-propenyl}-indan-1-one O-methyl oxime

Product 1

HCID 865954114-[4(2-Dimethylaminoethoxy)phenyl]-2-(1-methoxyiminoindan-5-yl)-1-pyridin-4-ylbutane-1,4-dione

Procedure

The title compound was prepared from the product of Step 1 and pyridine-4-carboxaldehyde using the method described in Example 1 Step 4; MS(ES+) m/e 486 [M+H]+.

Sources & evidence

ORD record
ord-1971b44ec3384f31a99ccebbb6b91c1f
Source dataset
uspto-grants-2007_11
Patent number
US07297694B2

Reaction notes

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