5-(5-Bromo-2-pyridin-4-ylfuran-3-yl)indan-1-one → 5-{5-[2-(2-Morpholin-4-ylethoxy)pyrimidin-5-yl]-2-pyridin-4ylfuran-3-yl}indan-1-one

HRID 1593426Notes

Reaction equation

HRID 1593426 reaction equation
C[Sn](C)(C)[C:3]1[CH:4]=[N:5][C:6]([O:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[N:7][CH:8]=1.Br[C:21]1[O:25][C:24]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)=[C:23]([C:32]2[CH:33]=[C:34]3[C:38](=[CH:39][CH:40]=2)[C:37](=[O:41])[CH2:36][CH2:35]3)[CH:22]=1>>[N:12]1([CH2:11][CH2:10][O:9][C:6]2[N:5]=[CH:4][C:3]([C:21]3[O:25][C:24]([C:26]4[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=4)=[C:23]([C:32]4[CH:33]=[C:34]5[C:38](=[CH:39][CH:40]=4)[C:37](=[O:41])[CH2:36][CH2:35]5)[CH:22]=3)=[CH:8][N:7]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 694283845-(5-Bromo-2-pyridin-4-ylfuran-3-yl)indan-1-oneHCID 694335014-[2-(5-Trimethylstannanylpyrimidin-2-yloxy)ethyl]morpholine

Product 1

HCID 694334975-{5-[2-(2-Morpholin-4-ylethoxy)pyrimidin-5-yl]-2-pyridin-4ylfuran-3-yl}indan-1-oneYield 48%

Procedure

The title compound (0.11 g, 48%) was prepared from the product of Step 2 and the product from Example 5 Step 9 using the method of Example 5 Step 10; MS(ES+) m/e 483 [M+H]+.

Sources & evidence

ORD record
ord-741cd7448daa4981a6b911fda13dcc8f
Source dataset
uspto-grants-2007_11
Patent number
US07297694B2

Reaction notes

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