4-(4-Acetylphenoxy)piperidine-1-carboxylic acid tert-butyl ester → 4-{4-[(E)-3-(1-Methoxyimino-indan-5-yl)allanoyl]phenoxy}piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:23])[CH3:22])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:24][O:25][N:26]=[C:27]1[C:35]2[C:30](=[CH:31][C:32]([CH:36]=O)=[CH:33][CH:34]=2)[CH2:29][CH2:28]1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:23])/[CH:22]=[CH:36]/[C:32]3[CH:31]=[C:30]4[C:35](=[CH:34][CH:33]=3)[C:27](=[N:26][O:25][CH3:24])[CH2:28][CH2:29]4)=[CH:17][CH:16]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
The title compound (0.9 g, 75%) was prepared from the product of Step 1 and the product of Example 1 Step 2 using the method of Example 2 Step 1. 1H NMR (CDCl3) 8.03 (2H, d, J 8.8 Hz), 7.80 (1H, d, J 15.6 Hz), 7.72 (1H, d, J 8.4 Hz), 7.56 (3H, m), 6.98 (2H, d J 8.8 Hz), 4.6 (1H, m), 4.01 (3H, s), 3.70 (2H, m), 3.35 (2H, m), 3.07 (2H, m), 2.92 (2H, m), 1.95 (2H, m), 1.80 (2H,m), 1.47 (9H, s).
Sources & evidence
- ORD record
- ord-bc4b0cf7c2c140f193327df9ce77c968
- Source dataset
- uspto-grants-2007_11
- Patent number
- US07297694B2
Reaction notes
Loading…