4-(4-Acetylphenoxy)piperidine-1-carboxylic acid tert-butyl ester → 4-{4-[(E)-3-(1-Methoxyimino-indan-5-yl)allanoyl]phenoxy}piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

The title compound (0.9 g, 75%) was prepared from the product of Step 1 and the product of Example 1 Step 2 using the method of Example 2 Step 1. 1H NMR (CDCl3) 8.03 (2H, d, J 8.8 Hz), 7.80 (1H, d, J 15.6 Hz), 7.72 (1H, d, J 8.4 Hz), 7.56 (3H, m), 6.98 (2H, d J 8.8 Hz), 4.6 (1H, m), 4.01 (3H, s), 3.70 (2H, m), 3.35 (2H, m), 3.07 (2H, m), 2.92 (2H, m), 1.95 (2H, m), 1.80 (2H,m), 1.47 (9H, s).

Provenance & Evidence