Dimethylformamide dimethyl acetal → 5-[2-((E)-3-Dimethylaminoallanoyl)furan-3-yl]indan-1-one O-methyloxime

HRID 1593442Notes

Reaction equation

HRID 1593442 reaction equation
[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[CH:17]=[CH:16][O:15][C:14]=3[C:18](=[O:20])[CH3:19])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.CO[CH:23](OC)[N:24]([CH3:26])[CH3:25]>>[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[CH:17]=[CH:16][O:15][C:14]=3[C:18](=[O:20])/[CH:19]=[CH:23]/[N:24]([CH3:26])[CH3:25])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 86213593HCID 86213593, compound

Product 1

HCID 865954205-[2-((E)-3-Dimethylaminoallanoyl)furan-3-yl]indan-1-one O-methyloximeYield 98%

Procedure

A solution of the product of Step 1 (0.15 g, 0.56 mmol) in N,N-dimethylformamide dimethyl acetal (5 ml) was heated at 100° C. for 18 hours. After cooling to room temperature, the solvent was removed in vacuo to afford the title compound (0.18 g, 98%); MS (ES+) m/e 325 [M+H]+.

Workup

  1. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-50c95f717d8a43889120c5122438a4c7
Source dataset
uspto-grants-2007_11
Patent number
US07297694B2

Reaction notes

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