Trifluoroacetic acid → HCID 86760576, compound

HRID 1593487Notes

Reaction equation

HRID 1593487 reaction equation
C([O:5][C:6]([C:8]1[O:9][C:10]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)=[C:11]([C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[C:18](=[N:22][O:23][CH3:24])[CH2:17][CH2:16]3)[CH:12]=1)=[O:7])(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>ClCCl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH3:24][O:23][N:22]=[C:18]1[C:19]2[C:15](=[CH:14][C:13]([C:11]3[CH:12]=[C:8]([C:6]([OH:7])=[O:5])[O:9][C:10]=3[C:25]3[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86760575HCID 86760575, compound

Product 1

HCID 86760576HCID 86760576, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Step 2 (4.74 g, 11.7 mmol) was dissolved in trifluoroacetic acid (50 ml) and dichloromethane (50 ml). The solution was stirred at room temperature for 3 hours and then evaporated in vacuo, azeotroping three times with dichloromethane. The resulting solid was triturated with diethyl ether, filtered and dried to afford the title product (5.46 g), which was used without further purification; MS (AP−) m/e 347 [M−H]−.

Workup

  1. customevaporated in vacuo
  2. customazeotroping three times with dichloromethane
  3. customThe resulting solid was triturated with diethyl ether
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-b2a2eb0dc78a433cb9cee9c98bf36ab6
Source dataset
uspto-grants-2007_11
Patent number
US07297693B2

Reaction notes

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