1-(1-Methyl-4-piperidinyl)piperazine → 1-(N-Boc-D-allo-Threoninyl)-4-(1-methylpiperidin-4-yl)-piperazine

HRID 1593495Notes

Reaction equation

HRID 1593495 reaction equation
[C:1]([NH:8][C@@H:9]([C:13]([OH:15])=O)[C@@H:10]([CH3:12])[OH:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:16][N:17]1[CH2:22][CH2:21][CH:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH2:19][CH2:18]1>O>[C:1]([NH:8][C@@H:9]([C:13]([N:26]1[CH2:25][CH2:24][N:23]([CH:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)[CH2:28][CH2:27]1)=[O:15])[C@@H:10]([CH3:12])[OH:11])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

4

Reactant 2

HCID 5663241-(1-Methyl-4-piperidinyl)piperazineHCID 6992543D-Allothreonine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)

Product 1

HCID 235402541-(N-Boc-D-allo-Threoninyl)-4-(1-methylpiperidin-4-yl)-piperazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from N-Boc-D-allo-threonine and 1-(1-methyl-piperidin-4-yl)piperazine using methods substantially equivalent to General Coupling Method 1. 1H NMR. ES-MS, m/z 385.5 (M+1)+. Analysis For C19H36N4O4.1.0 H2O: Calcd: C 56.69; H 9.52; N 13.92; Found: C 57.18; H 9.59; N 13.85.

Sources & evidence

ORD record
ord-9be10df096b6406e8ceefd049a2e3f0f
Source dataset
uspto-grants-2007_11
Patent number
US07297706B2

Reaction notes

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