HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Methyl-4-piperidinyl)piperazine → 1-(N-Boc-D-allo-Threoninyl)-4-(1-methylpiperidin-4-yl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Methyl-4-piperidinyl)piperazine | HCID 566324 | — |
| Reactant | (2R,3R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxybutanoic acid | HCID 6992543 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(N-Boc-D-allo-Threoninyl)-4-(1-methylpiperidin-4-yl)-piperazine | HCID 23540254 | — |
Reaction Steps
Prepared from N-Boc-D-allo-threonine and 1-(1-methyl-piperidin-4-yl)piperazine using methods substantially equivalent to General Coupling Method 1. 1H NMR. ES-MS, m/z 385.5 (M+1)+. Analysis For C19H36N4O4.1.0 H2O: Calcd: C 56.69; H 9.52; N 13.92; Found: C 57.18; H 9.59; N 13.85.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07297706B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-9be10df096b6406e8ceefd049a2e3f0f |
| Source note | uspto-grants-2007_11 |