Trifluoroacetic acid → HCID 22663050, compound

HRID 1593514Notes

Reaction equation

HRID 1593514 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[C:18]2[C:13](=[CH:14][N:15]=[CH:16][CH:17]=2)[N:12]([S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)(=[O:21])=[O:20])[CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:29][O:28][C:24]1[CH:23]=[C:22]([S:19]([N:12]2[C:13]3=[CH:14][N:15]=[CH:16][CH:17]=[C:18]3[C:10]([CH2:9][CH2:8][NH2:7])=[CH:11]2)(=[O:20])=[O:21])[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23521605HCID 23521605, compound

Product 1

HCID 22663050HCID 22663050, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of t-Butyl[2-{1-(3-methoxybenzenesulfonyl)-1H-pyrrolo[2,3-c]pyridin-3-yl}-ethyl]carbamate in CH2Cl2 is treated with trifluoroacetic acid, stirred for 2 h and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to afford the title final product.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe resultant residue is purified by preparative reverse phase HPLC

Sources & evidence

ORD record
ord-b72de41e69c04444b137b19cb456af6f
Source dataset
uspto-grants-2007_11
Patent number
US07297705B2

Reaction notes

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