Methanol → Methyl 2-(4-hydroxyphenoxy)-2-methylbutanoate

HRID 1593543Notes

Reaction equation

HRID 1593543 reaction equation
[CH3:1][CH:2](C)[C:3]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15]CC2C=CC=CC=2)=[CH:11][CH:10]=1)([CH3:7])[C:4]([O-:6])=[O:5].[CH3:24]O>[Pd]>[OH:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][C:3]([CH3:7])([CH2:2][CH3:1])[C:4]([O:6][CH3:24])=[O:5])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 86604654HCID 86604654, compound

Product 1

HCID 21111741Methyl 2-(4-hydroxyphenoxy)-2-methylbutanoate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of methyl-(4-(benzyloxy)phenoxy)-2-methylbutanoate (32 g) in 100 mL MeOH was hydrogenated using 10% Pd/C at 40 psi. The mixture was filtered through a pad of celite to remove the catalyst. The filtrate was concentrated to afford thick oily residue (21 g, quantitative).

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. customto remove the catalyst
  3. concentrationThe filtrate was concentrated
  4. customto afford thick oily residue (21 g, quantitative)

Sources & evidence

ORD record
ord-86b717274ce14d5da68fccbb693d3510
Source dataset
uspto-grants-2007_11
Patent number
US07297715B2

Reaction notes

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