Methane → HCID 69232679, compound

HRID 1593628Notes

Reaction equation

HRID 1593628 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]1[CH2:13][C:8]3(OCC[O:9]3)[CH2:7][CH2:6][C:5]2=1.C>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]1[CH2:13][C:8](=[O:9])[CH2:7][CH2:6][C:5]2=1

Participants

4

Reactant 2

HCID 297MethaneHCID 69236604HCID 69236604, compound

Product 1

HCID 69232679HCID 69232679, compoundYield 26.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared according to the procedure of Example 43 step C by replacing the 1,3,4,9-tetrahydrospiro[carbazole-2,2′-[1,3]dioxolane] with 6-fluoro-1,3,4,9-tetrahydrospiro[carbazole-2,2′-[1,3]dioxolane] (6.058 g, 0.0245 mol). The crude product was dissolved in warm methanol, treated with charcoal, filtered over Celite and the filtrate evaporated to dryness. The residue was slurried in a small amount of methanol, the off white solid collected and dried to provide the title compound (1.297 g), m.p. 165-167° C. MS (ES): [M−H]− @m/z 202.0.

Workup

  1. customThe title compound was prepared
  2. filtrationfiltered over Celite
  3. customthe filtrate evaporated to dryness
  4. customthe off white solid collected
  5. customdried

Sources & evidence

ORD record
ord-234ddb9c92c6456c8a651e58f9af98cc
Source dataset
uspto-grants-2007_11
Patent number
US07297704B2

Reaction notes

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