HCID 67206080, compound → HCID 66812220, compound

HRID 1593641Notes

Reaction equation

HRID 1593641 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][C@@H:7]([NH:15]C(=O)OCC3C=CC=CC=3)[CH2:6][C:5]2=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][C@@H:7]([NH2:15])[CH2:6][C:5]2=1

Participants

4

Reactant 1

HCID 67206080HCID 67206080, compound

Product 1

HCID 66812220HCID 66812220, compoundYield 110.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl [(3R)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]carbamate (240 mg, 0.71 mmol) in ethanol was added 20 mg of 10% palladium on carbon. Hydrogenation at 50 psi overnight, followed by filtration and concentration of the filtrate, afforded 160 mg of the title compound as an off-white solid.

Workup

  1. filtrationHydrogenation at 50 psi overnight, followed by filtration and concentration of the filtrate

Sources & evidence

ORD record
ord-f96f671da73b446bb9853e9aa30ce5e9
Source dataset
uspto-grants-2007_11
Patent number
US07297704B2

Reaction notes

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