Hydrazine hydrate (1:1) → HCID 178509224, compound

HRID 1593671Notes

Reaction equation

HRID 1593671 reaction equation
O.[NH2:2][NH2:3].[Br:4][C:5]1[CH:6]=[N:7][C:8](Cl)=[C:9]([CH:12]=1)[C:10]#[N:11]>C(O)C>[Br:4][C:5]1[CH:12]=[C:9]2[C:10]([NH2:11])=[N:3][NH:2][C:8]2=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 219482695-Bromo-2-chloronicotinonitrile

Product 1

HCID 178509224HCID 178509224, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine hydrate (19 ml, 391 mmol) was added to a stirred solution of 5-bromo-2-chloronicotinonitrile (34 g, 156 mmol) in ethanol (300 ml). The reaction mixture was stirred at reflux for 4 hours then the solvent was removed in vacuo. Water was added and the resulting solids were filtered, washed with water, and dried in vacuo to afford the title compound as a solid.

Workup

  1. temperatureat reflux for 4 hours
  2. customthe solvent was removed in vacuo
  3. additionWater was added
  4. filtrationthe resulting solids were filtered
  5. washwashed with water
  6. customdried in vacuo

Sources & evidence

ORD record
ord-62f335861d3643c98c4e7fa66cade030
Source dataset
uspto-grants-2007_11
Patent number
US07297792B2

Reaction notes

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