Piperidine → 4-Bromo-3-(piperidine-1-sulfonyl)-benzoic acid

HRID 1593688Notes

Reaction equation

HRID 1593688 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11](Cl)(=[O:13])=[O:12].[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 37373734-Bromo-3-(chlorosulfonyl)benzoic acid

Product 1

HCID 7679024-Bromo-3-(piperidine-1-sulfonyl)-benzoic acidYield 88%

Procedure

Compound 3.1 was prepared from 4-bromo-3-chlorosulfonyl-benzoic acid 2.1 and piperidine a1 in 88% yield according to general method B. MS (M−1)=346.

Sources & evidence

ORD record
ord-43c6919e63f04aac82982e4477e34e2e
Source dataset
uspto-grants-2007_11
Patent number
US07297796B2

Reaction notes

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