Piperidine → 4-Chloro-3-(1-piperidinylsulfonyl)benzoic acid

HRID 1593689Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11](Cl)(=[O:13])=[O:12].[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)(=[O:13])=[O:12]

Participants

Reactant 2

HCID 8082Piperidine

HCID 756134-Chloro-3-(chlorosulphonyl)benzoic acid

Product 1

HCID 7678994-Chloro-3-(1-piperidinylsulfonyl)benzoic acidYield 89%

Procedure

Compound 3.2 was prepared from 4-chloro-3-chlorosulfonyl-benzoic acid 2.2 and piperidine a1 in 89% yield according to general method B. MS (M−1)=302.

Sources & evidence

ORD record: ord-8e40a5e427e44af2964f7f5a1558de3d
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07297796B2

Reaction notes

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