Sodium Carbonate → HCID 16124832, compound

HRID 1593746Notes

Reaction equation

HRID 1593746 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([N:11]1[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]1=[O:21])=[N:5][NH:6]2.Cl[CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.C([O-])([O-])=O.[Na+].[Na+]>CN(C=O)C>[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([N:11]1[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]1=[O:21])=[N:5][N:6]2[CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 767274-(2-Chloroethyl)morpholineHCID 16125234HCID 16125234, compound

Product 1

HCID 16124832HCID 16124832, compoundYield 34.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of Example 162A (100 mg), 4-(2-chloroethyl)morpholine (48 mg), and Na2CO3 (82 mg) in DMF (5 mL) was heated overnight at 80° C., cooled to room temperature, and partitioned between 1N HCl and ethyl acetate. The aqueous layer was basified with 1N KOH and extracted with ethyl acetate. The extract was dried (MgSO4), filtered, and concentrated to provide 45 mg of the desired product. MS (ESI(+)) m/e 503 (M+H)+.

Workup

  1. custompartitioned between 1N HCl and ethyl acetate
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-a2e9f3e882554ba799572f07d37e1d3c
Source dataset
uspto-grants-2007_11
Patent number
US07297709B2

Reaction notes

Loading…