Piperidin-4-ol → HCID 21074074, compound

HRID 1593941Notes

Reaction equation

HRID 1593941 reaction equation
Cl[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:20]=[CH:19][C:18]2[NH:17][C:16]3[C:11](=[CH:12][C:13]([NH:21][C:22](=[O:26])[CH2:23][CH2:24]Cl)=[CH:14][CH:15]=3)[C:10](=[O:27])[C:9]=2[CH:8]=1)=[O:5].[OH:28][CH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[OH:28][CH:29]1[CH2:34][CH2:33][N:32]([CH2:2][CH2:3][C:4]([NH:6][C:7]2[CH:20]=[CH:19][C:18]3[NH:17][C:16]4[C:11](=[CH:12][C:13]([NH:21][C:22](=[O:26])[CH2:23][CH2:24][N:17]5[CH2:18][CH2:9][CH:10]([OH:27])[CH2:11][CH2:16]5)=[CH:14][CH:15]=4)[C:10](=[O:27])[C:9]=3[CH:8]=2)=[O:5])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 21074075HCID 21074075, compound

Product 1

HCID 21074074HCID 21074074, compound

Procedure

Chloroamide 13 (1.0 g, 2.5 mmol) was treated with 4-hydroxypiperidine (5 mL) according to the general aminolysis procedure to give the desired product JM-ACO-08 (776 mg, 58%) as a pale yellow/green solid.

Sources & evidence

ORD record
ord-9d376edd7d874a2b92536d964b407e4d
Source dataset
uspto-grants-2007_11
Patent number
US07300930B2

Reaction notes

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