HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → cis-2-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | (1R,2S)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate | HCID 56595230 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | cis-2-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylic acid | HCID 1512487 | 93.1% |
Reaction Steps
To 6.05 grams (22.3 mmol) of the ester of step 1 dissolved in 25 mL methanol was added 2.6 g (55.74 mmol) lithium hydroxide monohydrate dissolved in 10 mL water. The mixture was stirred for 48 hours, partitioned between ethyl acetate and 1 N HCl, dried over magnesium sulfate and concentrated to obtain 5.05 g of the crude (1R,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07300934B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-1a60637ecfbe41458c8e9c79125c24cf |
| Source note | uspto-grants-2007_11 |