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HRID1593985

反应详情

EQUATION

反应方程式

HRID 1593985 的结构方程式

REACTANTS

反应物

2
结构：O.[Li+].[OH-]
HCID168937

Lithium hydroxide hydrate

H3LiO2

结构：CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)OC(C)(C)C
HCID56595230

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1C(=O)O
HCID1512487

未命名化合物

收率 93.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

To 6.05 grams (22.3 mmol) of the ester of step 1 dissolved in 25 mL methanol was added 2.6 g (55.74 mmol) lithium hydroxide monohydrate dissolved in 10 mL water. The mixture was stirred for 48 hours, partitioned between ethyl acetate and 1 N HCl, dried over magnesium sulfate and concentrated to obtain 5.05 g of the crude (1R,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid.

WORKUP

后处理

  1. custompartitioned between ethyl acetate and 1 N HCl
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated