Ethanol → HCID 68530741, compound

HRID 1594006Notes

Reaction equation

HRID 1594006 reaction equation
[Na].CS([C:6]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[S:8][N:7]=1)(=O)=O.[CH2:17]([OH:19])C>>[CH3:17][O:19][C:6]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[S:8][N:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 5360545Sodium2×HCID 68532082HCID 68532082, compound

Product 1

HCID 68530741HCID 68530741, compoundYield 77%

Conditions

Temperature
50 °C

Procedure

100 mg (4.0 mmol) of sodium were added to ethanol (20 ml). After reaction of the sodium was complete, 500 mg (2.0 mmol) of 1-(3-methanesulfonyl-[1,2,4]-thiadiazol-5-yl)piperazine were added and the mixture was subsequently stirred at 50° C. 2 h. The cooled reaction solution was poured into a satd aq. NaCI soln cooled to 0° C. This mixture was extracted with EA. The organic phase was dried over MgSO4, filtered and concentrated in vacuo. 310 mg (1.54 mmol, 77%) of 1-(3-methoxy-[1,2,4]-thiadiazol-5-yl)piperazine were obtained.

Workup

  1. custom2 h
  2. customThe cooled reaction solution
  3. temperaturecooled to 0° C
  4. extractionThis mixture was extracted with EA
  5. dry with materialThe organic phase was dried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4fd2b1e0e9d943a295480caa514c1955
Source dataset
uspto-grants-2007_11
Patent number
US07300939B2

Reaction notes

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